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Figure 1. A. shows that the supernatant from the culture A was allowed to contact,  these T cells were added to freshly isolated T cells. These T cells then also expressed reduced levels of TCR-β on their surface. Therefore, it appears that contact between S. Typhimurium and T cells induces secretion of a T cell inhibitor capable of down-modulating TCR-β expression. B. Trypsin-treatment of the supernatant from culture B were allowed to contact T cells which destroyed the inhibitory activity of the supernatant. This suggest that that the secreted factor responsible for TCR-β down-modulation likely is a protein.